Are you getting sicker, or more likely than you think to get cancer?
Researchers at the University of California, San Francisco (UCSF) found that people who get diabetes are more likely in fact to have cancer than people who don’t.
Their study, published in the Proceedings of the National Academy of Sciences, found that when looking at a population of 4,716 people, those who had diabetes were significantly more likely as the odds of developing cancer.
People with diabetes are estimated to have an average of 7,000 extra cancer cells per square centimeter (sqcm) of their body compared to people without diabetes.
However, the researchers note that these findings could not prove causality.
In other words, it’s not yet known whether diabetes actually leads to more cancer cells, or if people with diabetes have different cancers from those without diabetes because of differences in their diet, lifestyle or the type of cells they have.
The study also found that the risk of developing a cancer-causing gene or cancer-promoting protein was higher in people who had type 2 diabetes than in people with type 1 diabetes.
People who were more likely were also more likely not to have normal blood pressure, lower cholesterol and lower blood sugar levels, as well as to have other metabolic problems.
“This is a very exciting study,” said study author Michael J. Roper, a UCSF professor of medicine and the director of the UCSF Diabetes Research Center.
“The findings support the idea that diabetes is not simply a risk factor for cancer.”
This new research is the result of decades of work by UCSF researchers on the link between diabetes and the development of cancer.
In 2005, researchers from UCSF and the National Cancer Institute reported that diabetes and cancer risk were significantly associated.
UCSF published a study in 2016 that concluded that the link was due to lifestyle, not genetics.
But in 2017, Roper and his colleagues followed up with a larger group of people who were followed up for 15 years to determine whether the same results hold true for cancer risk.
The team found that diabetes was a significant predictor of developing cancers in both the people with cancer and people without cancer, but that it was the lifestyle factors that were the most predictive.
People in the study with diabetes were more than twice as likely as those without to have more than one type of cancer, and to have low HDL cholesterol, a marker of high blood sugar.
The researchers also found a strong association between diabetes, high blood pressure and diabetes-related disease, but they couldn’t prove causally linked.
They didn’t find any link between smoking and cancer, which is common among people with Type 2 diabetes.
It’s not clear why the link is so strong, but the researchers say they don’t know why people who are overweight and who are obese have a higher risk of cancer and are less likely to take preventive measures.
For people who have type 1 and type 2, the link could be due to differences in how they metabolize carbohydrates, the study authors say.
While the study doesn’t definitively prove cause and effect, it does show that diabetes-linked cancer is a risk, and that people with high blood glucose levels are at a greater risk of getting cancer.
“It’s important to recognize that diabetes has a complex relationship to cancer and other disease,” Roper said.
“While the overall risk of a person developing diabetes is very low, we need to be aware that diabetes can increase cancer risk in people and that this could lead to a higher likelihood of cancer in some people.”
The study, led by UCSFs Dr. R. Nathan Hallett and Dr. Stephen C. O’Connor, will be presented at the American Cancer Society annual meeting in New Orleans in April.